RNA Biology in Dementia Research Group

Based across 2 campuses, the University of Sydney’s Brain and Mind Centre and the University of NSW School of Biotechnology and Biomolecular Sciences. Their research is primarily focussed on understanding the functions of the ‘dark matter of the genome’ – the tens if not hundreds of thousands of non-protein-coding RNAs that are expressed dynamically during development and in specific cells and precise subcellular locations in the brain. Projects include the role of these nocoding RNAs in brain development, learning, motor coordination and disease, as well as their structure function-relationships.

Projects

Functional analysis of long noncoding RNAs expressed in the brain – John Mattick
Exploring the brain transcriptome in FTD using bulk and single-nuclei sequencing – Sandy Pineda, John Mattick, Glenda Halliday, Clement Loy
High frequency of intron retention and clustered H3K4me3-marked nucleosomes in short first introns of human long non-coding RNAs – Pinki Dei
Functional analysis of long noncoding RNAs expressed in the brain – Pinki Dei
Deciphering the structure-function relationships of long non-coding RNAs – Pinki Dei