Dr Tomas Kavanagh

Dr Tomas Kavanagh, Postdoctoral Research Fellow, The University of Sydney.

Tomas is a postdoctoral research associate at the University of Sydney. He completed his PhD on the role of alternative splicing and long non-coding RNAs in Parkinson’s disease at the Garvan institute of Medical research and the University of New South Wales in 2019.

Tomas is currently focused on the role of Tau in multiple neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy and Pick’s disease. To explore this, he is developing tissue culture models of Tauopathies and Alzheimer’s disease using isolated Tau and Tau with beta-amyloid to investigate protein interactions that may drive disease processes. He is using proteomic approaches to identify protein interactions with Tau specific to each disease. He is also using bioinformatic approaches to identify novel disease mechanisms from Tau proteomic and transcriptomic datasets across multiple Tauopathies.

Forefront Group:

  • UNSW/BMC Biology in Dementia Research Group
  • BMC DAMD Alzheimer’s disease Research Group

Neurodegeneration of interest



  • Tissue culture
  • Bioinformatics
  • Proteomics

Affiliate Organisations

University of Sydney

Specific Skills:

  • Bioinformatics
  • Genomics
  • RNA-Seq library preparation
  • Differential gene expression
  • Alternative Splicing Analysis
  • Proteomics
  • Meta-analysis
  • DNA/RNA Isolation
  • SDS-PAGE and Western Blotting
  • Confocal Immunofluorescent Imaging
  • Image Analysis
  • Mammalian and Primary Tissue Culture


  • Interaction of RNA binding proteins and tau in tauopathies
  • Differential expression and alternative splicing in tauopathies CBD, ALS, FTD, PSP, PiD and AD
  • Protein interactions with phosphorylated tau in FTD; PSP, PiD and CBD
  • Mechanistic tissue culture models of strain specific Tau PHFs (from PiD, PSP and AD) toxicity