The Alzheimer’s disease research group is part of the Dementia and movement Disorder (DAMD) Lab at the Brain and Mind Centre (BMC). The goal of our research is to identify new drug targets and biomarkers for Alzheimer’s disease by comprehensively mapping all the protein changes that occur in the brain during Alzheimer’s disease. We are particularly interested in identifying protein changes that are closely associated with the characteristic neuropathological features present in Alzheimer’s disease brains (amyloid plaques and neurofibrillary tangles) and those found in neuron populations that are particularly vulnerable in the disease. To do this we use a state-of-the-art proteomics approach that allows us to map thousands of protein changes at once, which provides a bird’s eye view of the disease process in Alzheimer’s disease and allows us to pinpoint those particular protein changes that are new potential drug targets or biomarkers. We are also currently working with the most promising new drug targets that we have identified so far to determine how they are involved in Alzheimer’s disease.