Jessica Chedid, Adahir Labrador-Garrido, Siying Zhong, Woojin S. Kim, Glenda M. Halliday, Nicolas Dzamko. A small molecule Toll-like receptor antagonist rescues α-synuclein fibril pathology DOI: of Biological Chemistry

This paper provides insight into how TLR2 activation may promote α-synuclein pathology in PD using a Pre-formed fibril pathology model, which can be rescued by a novel small molecule TLR2 antagonist, and supports that TLR2 may be a potential therapeutic target for the treatment of PD.