Professor Lars Matthias Ittner

Professor Lars Matthias Ittner, Director, Dementia Research Centre, NHMRC Principal Research Fellow, Macquarie University.

Lars is the Director of the Dementia Research Centre and Professor for Neuroscience in the Faculty of Medicine at Macquarie University. Lars graduated in Medicine from the University of Ulm in Germany and received his M.D. from the University of Zurich in Switzerland in 2002. This was followed by postdoctoral fellowships at the University of Zurich, where he studied neuronal stem cells and signalling pathways, and after moving to Australia in 2005, at the University of Sydney, focusing on basic pathomechanisms underlying neurodegenerative diseases. He held faculty appointments at the University of Sydney and the University of New South Wales before joining Macquarie University in 2018 to build the Dementia Research Centre. Lars was a German Research Foundation Fellow and is a current NHMRC Principal Research Fellow. He has published over 140 papers with over 12,000 citations, including in leading scientific journals, such as Science, Cell and Neuron. He received the ASBMB Merck Research Medal 2017 for his paradigm-shifting work in Alzheimer’s disease. He was awarded over $40 million in competitive grant funding. He is chief investigator on the NHMRC Program Grant ForeFront and led consecutive NHMRC (7x) and ARC (7x) projects since 2007.

Forefront Group:

  • Macquarie University Dementia Research Centre (DRC) Dementia Research Group Leader

Affiliate Organisations

Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia

Neurodegeneration of interest:

AD, FTD, MND, stroke, seizures, TBI, Ageing


  • Medical Doctor
  • Genetics
  • Molecular biology

Specific Skills:

  • Transgenic animal models of neurodegenerative diseases
  • Molecular mechanisms in neurodegeneration
  • Novel therapies for neurodegenerative diseases


  • Ittner LM (PI), Ke YD. MND Australia Peter Stearne Familial MND Research Grant, 2018-2019 Investigating the role of TDP-43 Motor Neuron Disease, led by PI Ittner.
  • Ittner LM (PI). NHMRC Principle Research Fellowship 1136241, 2018-2022
  • Halliday GM, Mattick J, Hodges J, Kiernan M, Piguet O, Kril J, Ittner LM (co-PI), Kassiou M. NHMRC Program 1132524, 2018-2022 Research consortium on frontotemporal dementia and motor neurodegenerative syndromes. co-PI Ittner is responsible for all animal work.
  • Ittner A, Ittner LM (co-PI). ARC DP200102396, 2020-2024 Study on the role of tau in neuronal physiology, co-led by PI Ittner
  • Ittner LM (PI). ARC DP170100781, 2017-2019 Study the role of tau interactions in neuronal physiology, led by PI Ittner
  • Ittner LM (PI), Ittner A. ARC DP170100843, 2017-2019 Study the neuroendocrine regulation of memory and other types of behaviour led by PI Ittner.
  • Ittner LM (PI), Housley G, Kassiou M, Karl T, van Eersel J. NHMRC Project 1081916, 2015-2019 Studying changes at the post-synapse in Alzheimer’s disease, led PI Ittner