After completing an Undergraduate Masters in Molecular and Cellular Biology Nicolle started her career as a transgenic technologist at the Francis Crick Institute, London. There, she performed genome editing strategies in mice, with a specialisation in mouse and human stem cell culture and manipulation. She is currently a member of the International Society for Transgenic Technologies (ISTT). Nicolle joined the Transgenic Animal Unit (within the Dementia Research Unit) at the University of New South Wales in 2017 and subsequently joined the Genetic Manipulation team as part of the Dementia Research Centre at Macquarie University, to further contribute to technology development in field of transgenics. She primarily worked in design and execution of strategies for generation of murine models of disease. In January 2020 she embarked on her Master of Research in the Dementia Research Centre at Macquarie University, progressing onto her PhD candidature in March 2021. Her project is centred on understanding the role of tau in epileptic encephalopathies, with particular focus on aligning mechanisms and potential therapeutic strategies across multiple neurological disorders.