The Dementia Research Centre (DRC) Motor neuron disease research group work is based within the Department of Biomedical Sciences and the Faculty of Medicine, Health and Human Sciences in MQ Health. This group explores current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches, along with investigating functions of pathogenic mutations in neurodegenerative diseases.