Project - Neural signatures of disease spread and evolution in motor neurodegenerative syndromes
Project with a disease tag
Motor Neuron Disease
Professor Matthew Kiernan
Research Project Description
Motor neuron disease (MND) is a rapidly progressive neurodegenerative disorder, linked clinically, pathologically and genetically to frontotemporal dementia. There is no significant disease modifying therapy and half of sufferers die within 3 years of diagnosis. To date, large multi-centre drug trials based on pre-clinical models of disease have all shown negative results, highlighting an urgent need for a greater understanding of disease mechanisms in the earliest stages of MND, and the development of validated markers of disease activity, including ways to identify individuals during the pre-symptomatic stage of disease.
The aim of the current project is to model stages of disease evolution in MND, in-vivo, from its earliest stage using cutting edge multi-modal neuroimaging techniques in combination with artificial intelligence-based modelling. Through our research, we have identified selective patterns of change affecting structural pathways of the brain associated with clinical symptoms and phenotypes. We are currently working on translating these findings into clinical models for predicting disease trajectory using deep learning neural networks.
Project related links:
Information on our MND research clinic can be accessed here - https://sydney.edu.au/brain-mind/patient-services/forefront-ageing-and-neurodegeneration-clinics/forefront-clinic-motor-neurone-disease-frontotemporal-dement.html