Dr Matthew Georgiades

Matthew is PhD scholar under Professor Simon Lewis at the Brain and Mind Centre. He is also a junior doctor training at Sydney’s Royal Prince Alfred Hospital. His research interest lies in the patho-neurophysiology behind gait freezing, a complex and highly disabling symptom in Parkinson’s disease. His current work involves analysis of neuronal signals recorded directly from the subthalamic nucleus of patients undergoing deep brain stimulation surgery while they perform a virtual reality task designed to trigger freezing episodes in real time. His work is supported by the RA Money Postgraduate Research Scholarship in Neuroscience. Matthew’s work has featured in journals Brain and Neuroscience and has been presented at numerous international meetings among highlighted selections of abstracts. He has also co-authored a number of significant research publications from our research group. He is the recent recipient of the Bierzonski Burczyk Foundation Prize and in 2019 his work earned the Royal Prince Alfred Hospital President’s Prize for Research. Matthew is a regular at Parkinson’s NSW fundraising and community events and he is also passionate about teaching medical students and junior doctors. Outside of work, he is a keen lover of the outdoors and enjoys pursuing his interest in high altitude trekking and mountaineering.

Forefront Group: Parkinson’s Dementia Lewy Bodies Research Group


Prof. Simon Lewis

Affiliate Organisations:

Brain and Mind Centre, Royal Prince Alfred Hospital, Central Clinical School, Faculty of Medicine and Health, University of Sydney


  • Neurophysiology
  • Deep Brain Stimulation
  • Movement disorders
  • Clinical Assessment in Parkinson’s Disease

Neurodegeneration of interest:


Specific Skills:

  • Medical Doctor
  • Clinical Researcher
  • Deep Brain Stimulation Recordings
  • Virtual Reality

Project - Investigating the role of the subthalamic nucleus in freezing of gait in Parkinson's disease

Project tag with a disease

Parkinson’s disease

Research Project Description

Freezing of gait is a disabling symptom commonly experienced in Parkinson's disease where patients describe their feet as being suddenly ‘frozen’ to the floor while walking. Direct neuronal recordings are taken intraoperatively from electrodes implanted within the subthalamic nucleus during deep brain stimulation surgery while patients perform a virtual reality walking task in real time. EMG from the lower limbs is also recorded and correlated with direct neuronal recordings from the subthalamic nucleus. These signals are then analysed via time frequency analysis to elucidate the changes in subthalamic nucleus firing in association with freezing episodes triggered by the virtual reality paradigm. This research offers unprecedented insight into the neurobiology underlying gait freezing in Parkinson’s disease and will hopefully facilitate development of novel therapies for this devastating symptom.

Key Publications from this project

  • Georgiades MJ, Shine JM, Gilat M, McMaster J, Owler B, Mahant N, Lewis SJG. Hitting the brakes: pathological subthalamic nucleus activity in Parkinson’s disease gait freezing. Brain 142(12); 3906-3916.
  • Georgiades MJ, Gilat M, Martens KAE, Walton CC, Bissett PG, Shine JM, Lewis SJG. Investigating motor initiation and inhibition deficits in patients with Parkinson’s disease and freezing of gait using a virtual reality paradigm. Neuroscience 337; 153-162.