Dr Fiona Bright

Dr Fiona Bright, Research Fellow, Macquarie University.

Fiona completed a PhD in Medicine in 2017 at the University of Adelaide. Her PhD investigated the brainstem neuropathology underlying sudden infant death syndrome (SIDS). During her PhD, Fiona was awarded an International SIDS Fellowship funded by Rivers Gift and spent 18 months at Harvard University Medical School/Boston Childrens Hospital. Following this Fiona received the 2017 Kaarene Fitzgerald SIDS Postdoctoral Research Fellowship funded by RedNose Australia where she continued to undertake SIDS research at the University of Adelaide. In 2018, Fiona sought new challenges and took up a Postdoctoral role with the NHMRC Funded ForeFront research group at the University of Sydney, to investigate neuroimmune-mediated mechanisms in frontotemporal dementia (FTD). In 2020, Fiona was awarded a Macquarie University Research Fellowship (MQRF) to undertake research at the Dementia Research Centre with Prof Lars Ittner and Assoc Prof Yazi Ke. Fiona's current research interests include; neuroimmune and neuroinflammatory mechanisms/pathways underlying the neuropathology associated with neurodegeneration, with a specific focus on the innate immune complement cascade and TDP-43 pathology in frontotemporal dementia and amyotrophic lateral sclerosis. 

Forefront Group:

  • Macquarie University Dementia Research Centre (DRC) Dementia Research Group

Affiliate Organisations

Macquarie University, Sydney University ForeFront

Neurodegeneration of interest:



  • Neuropathology
  • Neuroinflammation
  • Molecular biology

Specific Skills:

  • Neuropathological investigation
  • Histology (immunohistochemistry and immunofluorescence)
  • Post-mortem human and mouse brain tissue handling and dissection
  • Tissue receptor autoradiography
  • RNA-scope in-situ hybridisation (ISH)
  • Animal model microsurgery
  • Transgenic mouse models
  • AAV/shRNA administration in transgenic mouse models
  • Cell culture
  • qPCR
  • Western Blot
  • Flow Cytometry
  • MACS/FACS cell analysis,cell-culture
  • RNA and DNA sequencing
  • Statistical analysis
  • Bioinformatics and microscopy


  • CI: Role of the innate immune complement pathway and neuroinflammation underlying neurodegeneration in frontotemporal dementia and amyotrophic lateral sclerosis; the quest for specific biomarkers and novel therapeutics.