Dr Fabien Delerue

Dr Fabien Delerue, Head of the Genome Editing at Macquarie (GEM), Senior Lecturer, Macquarie University.

Fabien is the Head of the Genome Editing at Macquarie (GEM), a transgenic core of the Dementia Research Centre (DRC). The DRC is a leading discovery-based research centre established in 2018 at Macquarie University. Fabien graduated from the University of Bordeaux in France and received his PhD from the University of Sydney. Fabien gained his first research experience in the preclinical CNS Centre of Hoffmann-La Roche Ltd (Basel, Switzerland) where he became an expert in in vivo activities (i.e. animal models of diseases). In 2013, Fabien moved to the University of New South Wales, where he became Lecturer and managed the Transgenic Animal Unit. In 2018, he became Senior Lecturer and joined Macquarie University to head the GEM transgenic facility. His research focuses on developing new genome editing and gene transfer techniques particularly applicable to dementia. In parallel, Fabien developed a research program on rare genetic disorders

Forefront Group:

  • Macquarie University Dementia Research Centre (DRC) Dementia Research Group

Affiliate Organisations

Macquarie University

Neurodegeneration of interest:

AD, FTD, MND, stroke, seizure, ageing


  • Functional genetics
  • Genome editing
  • Animal models

Specific Skills:

  • Molecular Biologist
  • Genome Engineer
  • Assisted Reproductive Technologies expert


  • Mattick JS, Delerue F, Mercer T. ARC Discovery project 2021. Functional analysis of long noncoding RNAs expressed in the brain
  • Ke Y, van Hummel A, Au C, Ariawan D, Delerue F, Ittner LM. Betty and John Laidlaw MND Research Prize 2021. Novel therapeutic strategies targeting TDP-43 in Motor Neuron Disease
  • Delerue F, Maselko M, Ittner LM, Edwards O. CSIRO-MQ collaborative research agreement 2020-2022. Develop, advance, and apply vertebrate genome editing technologies to deliver projects in biosecurity, health, and agriculture
  • Maselko M, Ittner LM, Delerue F. CSIRO-MQ collaborative research agreement 2020-2022 Exploring technical feasibility of vertebrate pest population control with CRISPR Base-editor methods
  • Delerue F, Ittner LM. Australian FOXG1 foundation grant 2019. Investigating the pathophysiology of FOXG1 syndrome
  • Fath T, Gunning P, Klotzsch E, Karl T, Delerue F, Brandt R. ARC Discovery project 2017. Defining the spatial and temporal regulation of neurite branching