Project - Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests (PhD project, 2018-2021)
Disease area:
Primary progressive aphasia
Research Project Description
Primary progressive aphasia (PPA) comprises three main variants: logopenic (lv-PPA), non-fluent (nfv-PPA) and semantic (sv-PPA). Differentiating the language profiles of the PPA variants remains challenging, especially between lv-PPA and nfv-PPA. Accordingly, there may be advantages in using tools that tap into other cognitive domains and circumvent language, to improve diagnosis. David’s PhD has investigated these ‘other’ cognitive domains, including visuospatial abilities, non-verbal memory, and attention. The findings from his research suggest that brief neuropsychological assessment of cognition above and beyond language can improve the diagnostic accuracy of PPA.
Key Publications from this project
- Foxe, D., Irish, M., Roquet, D., Scharfenberg, A., Bradshaw, N., Hodges, J. R., ... & Piguet, O. (2020). Visuospatial short-term and working memory disturbance in the primary progressive aphasias: Neuroanatomical and clinical implications. Cortex, 132, 223-237.
- Foxe, D., Irish, M., Hu, A., Carrick, J., Hodges, J. R., Ahmed, R. M., ... & Piguet, O. (2021) Longitudinal cognitive and functional changes in primary progressive aphasia. Journal of Neurology, 1-11.
Infographic / Medical Diagram / Scientific Diagram / Picture
https://www.youtube.com/watch?v=KKT_WxivdqE