Optimise Sleep in Brain Ageing and Neurodegeneration

Within ForeFront, the Centre of Research Excellence to optimise sleep in Brain Ageing and Neurodegeneration (CogSleep) team brings together sleep researchers, sleep clinicians, neurobiologists, neuroscientists, neurologists and neuropsychologists to understand the role sleep  and sleep disorders in the development of neurodegenerative disorders. Sleep is an essential component of healthy brain ageing. Sleep and circadian disturbances are key characteristics in established neurodegenerative diseases including dementia and Parkinson’s disease. There is now growing evidence that sleep disturbance may accelerate neurodegeneration and cognitive decline and increases the risk of developing dementia. Using new technologies including remote monitoring of sleep including wearables and bedables; HDEEG, we are assessing the effect of various treatments for sleep disturbance and disorders, such as sleep apnea treatments, digital insomnia therapies and melatonin and their effect on cognition and markers of neurodegeneration.

  • "Local Sleep" in the Awake Brain: An Underlying Cause of Neurobehavioural Deficits in Sleep Apnea? – Angela D'Rozario
  • Sleep, plasticity and neurodegeneration: Enhancing sleep to prevent cognitive decline in Mild Cognitive Impairment – Angela D'Rozario
  • The effects of long-term low-dose colchicine on cognition and brain health in patients with established coronary artery disease- a randomized controlled study – Camilla Hoyos
  • Targeting the heart to optimise healthy brain ageing in different at-risk populations across adulthood – Camilla Hoyos
  • Brain oxidative stress and cognitive function in older adults with diabetes and pre-diabetes who are ‘at risk’ for dementia – Camilla Hoyos
  • Delineating relationships between sleep-wake disturbances, brain changes, dementia risk factors and the accumulation of dementia pathology – Andrew McKinnon
  • The Impact of Sleep Disturbance on Sleep Dependent Emotional Memory Consolidation: An Investigation of Late-Life Depression – Andrea Ricciardello - PhD

Meet our Research Group

Professor Sharon Naismith

NHMRC Dementia Leadership Fellow, USyd

  • Clinical Neuropsychologist
  • Cognitive Neuroscientist
  • Neuroimaging Analyst

Professor Ron Grunstein

Senior Principal Research Fellow, Professor of Sleep Medicine, USyd

  • Sleep Disorder
  • Sleep Apnea
  • Chronobiology

Professor Simon Lewis

Professor of Cognitive Neuroscience, USyd

  • Neuroimaging
  • Neurophysiology
  • Clinical Trials

Professor Glenda Halliday

NHMRC Leadership Fellow & Professor of Neuroscience, USyd

  • Neuropathology
  • Biomarkers
  • Genetics

Dr Angela D’Rozario

Clinical sleep neurophysiologist and Senior Research Fellow, USyd

  • Sleep and Sleep Disorders
  • Neurophysiology
  • High-density Electroencephalography

Dr Camilla Hoyos

NHMRC-ARC Dementia Research Fellow, USyd

  • Sleep Disorders
  • Sleep
  • Clinical Trials

Dr Andrew McKinnon

Dementia Australia Research Foundation Postdoctoral Research Fellow; Clinical Neuropsychologist, USyd

  • Neuroimaging
  • Neuropsychology
  • Statistics

Dr Loren Mowszoski

NHMRC-ARC Dementia Research Development Fellow, Clinical Neuropsychologist, USyd

  • Neuropsychology
  • Cognitive Intervention
  • Behavioural Research

Dr Yue Yang

Postdoctoral researcher, USyd

  • Neuropathology
  • Tissue Imaging
  • Biomarkers

Andrea Ricciardiello

PhD Student

The Impact of Sleep Disturbance on Sleep Dependent Emotional Memory Consolidation: An Investigation of Late-Life Depression

Supervisors: Sharon Naismith, Angela D’Rozario, Rick Wassing, Fiona Kumfor


Shawn Dexiao Kong

PhD Student

To examine autonomic function during sleep, via heart rate variability, in older adults at risk of dementia, and how nocturnal autonomic function is linked to the morphological and functional integrity of the brain

Supervisors: Prof Sharon Naismith, Dr Camilla Hoyos, A/Prof Craig Phillips, Dr Andrew McKinnon, Dr Craig Gordon