Motor neuron disease primarily affects the motor system and is very rapidly progressive. RNA binding proteins are largely affected but the mechanisms involved are still poorly understodd, except for genetic forms of the disease (a minority of people). Our Dementia with Lewy body research group is part of the Dementia and Movement Disorder (DAMD) laboratory based at the Brain and Mind Centre (BMC) aims to determine the cell types involved, when they become abnormal and what is the principal change that could be targeted therapeutically.